Publications

A current list of publications on PudMed can be found here.

Patterning and polarization of cell by intracellular flow.  R. Illukkumbura, T. Bland, and N.W. Goehring. Current Opinion in Cell Biology (2020). Publisher Site

Part of the PolarNet ITN special issue on Cell Architecture


A cell size threshold limits cell polarity and asymmetric division potential.  L. Hubatsch, F. Peglion, J.D. Reich, N.T.L. Rodrigues, N. Hirani, R. Illukkumbura and N.W. Goehring. Nature Physics (2019). Publisher Site - Open Access Link 

See also: Size flips symmetry switch & For embryo’s cells, size can determine fate 



Switching states: dynamic remodeling of polarity complexes as a toolkit for cell polarisation.  F. Peglion and N.W. Goehring. Current Opinion in Cell Biology 60:121-130 (2019). Publisher site - Open Access (Author Manuscript)



Anterior-enriched filopodia create appearance of asymmetric membrane micro domains in polarizing C. elegans zygotes.  N. Hirani, R. Illukkumbura, T. Bland, N. Hirani, G. Mathonnet, D. Suhner, A.C. Reymann, N.W. Goehring. Journal of Cell Science (2019). Open Access Link 


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Reich2019

Regulated activation of the PAR polarity network ensures a timely and specific response to spatial cues.  J.D. Reich, L. Hubatsch, R. Illukkumbura, F. Peglion, N. Hirani, N.W. Goehring. Current Biology 29(12):1911-1923.e5 (2019). Open Access Link 

See Cell Polarity: Getting the PARty Started.



Guided self-organized pattern formation in cell polarity establishment.  P. Gross*, K.V. Kumar*, N.W. Goehring, J.S. Bois, C. Hoege, F. Jülicher, S.W. Grill. Nature Physics 15:293-300 (2019). Publisher - Open Access (PMC) 

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aPKC cycles between functionally distinct PAR protein assemblies to drive cell polarity.  J. Rodriguez*, F.P. Peglion*, J. Martin, L. Hubatsch, J. Reich, N. Hirani, A.G. Gubieda, J. Roffey, A. Ribeiro-Fernandes, D. St Johnston, J. Ahringer, and N.W. Goehring. Developmental Cell. 42:400-415 (2017)  *Contributed Equally. Open Access Link

Intracellular scaling mechanisms (review). S. Reber and N.W. Goehring. Cold Spring Harbor Perspectives in Biology. 7:a019067 (2015).  Web


PAR polarity: From complexity to design principles (review). N.W. Goehring. Experimental Cell Research. 328(2):258-266 (2014). Web


Parameter-space topology of models for cell polarity.  P. Khuc Trong, E.M. Nicola, N.W. Goehring, K.V. Kumar and S.W. Grill.  New Journal of Physics. 16:065009 (2014).  Web

Cell polarity: Mechanochemical patterning (Review).  N.W. Goehring and S.W. Grill.  Trends in Cell Biology. 23(2):72-80 (2013). Web

Organelle growth control through limiting pools of cytoplasmic components (Review).  N.W. Goehring and A.A. Hyman.  Current Biology. 22(9):R330-9 (2012).  Web


Polarization of PAR proteins by advective triggering of a pattern-forming system.  N.W. GoehringP. Khuc Trong, J.S. Bois, D. Chowdhury, E.M. Nicola, A.A. Hyman, and S.W. Grill.  Science. 334(6059):1137-1141 (2011).  Web

See Going with the flow: an elegant model for symmetry breaking and Cell polarization: Mechanical switch for a chemical reaction

Goehring2011JCB

PAR diffuse freely across the anterior-posterior boundary in polarized C. elegans embryos.  N.W. Goehring, C. Hoege, S.W. Grill, and A.A. Hyman.  Journal of Cell Biology. 193(3):583-594 (2011).  Web / PDF

See In Focus: PAR proteins cross the boundary.

Goehring2010BiophysJ

FRAP analysis of membrane-associated proteins: lateral diffusion and membrane-cytoplasmic exchange.  N.W. Goehring, D. Chowdhury, A.A. Hyman, and S.W. Grill.  Biophysical Journal. 99(8):2443-2452 (2010).  Web / PDF

Current version of FRAP analysis software available here.

Redemann2010PLoSOne

Membrane invaginations reveal cortical sites that pull on mitotic spindles in one-cell C. elegans embryos.  S. Redemann, J. Pecreaux, N.W. Goehring, K. Khairy, E.H.K. Stelzer, A.A. Hyman and J. Howard.  PLOS One. 5(8): e12301 (2010).  WebPDF


Hoege2010CurrBiol

LGL can partition the cortex of the one-cell Caenorhabditis elegans embryos into two domains.  C. Hoege, A.T. Constantinescu, A. Schwager, N.W. Goehring, P. Kumar, and A.A. Hyman.  Current Biology. 20(14):1296-1303 (2010).  Web / PDF

See Cell polarity: Keeping worms LeGaL.

Rapid β-lactam-induced lysis requires successful assembly of the cell division machinery.  H.S. Chung*, Z. Yao*, N. W. Goehring*, R. Kishony, J. Beckwith and D. Kahne. PNAS 106(51):21872-21877 (2009). *Equal contribution.  WebPDF


Artificial septal targeting of Bacillus subtilis cell division proteins in Escherichia coli: an interspecies approach to the study of protein-protein interactions in multiprotein complexes.  C. Robichon, G. F. King, N. W. Goehring and J. Beckwith.  Journal of Bacteriology 190(18):6048-59 (2008).  PDF

Role for the nonessential N terminus of FtsN in divisome assembly.  N. W. Goehring, C. Robichon and J. Beckwith.  Journal of Bacteriology 189(2):646-9 (2007).  PDF

Mutants, suppressors, and wrinkled colonies: mutant alleles of the cell division gene ftsQ point to functional domains in FtsQ and a role for domain 1C of FtsA in divisome assembly.  N. W. Goehring, I. Petrovska, D. Boyd and J. Beckwith.  Journal of Bacteriology 189(2):633-45 (2007).  PDF


Premature targeting of cell division proteins to midcell reveals hierarchies of protein interactions involved in divisome assembly.  N. W. Goehring, M. D. Gonzalez and J. Beckwith.  Molecular Microbiology 61(1):33-45 (2006).  PDF

See  The order of the ring: Assembly of Escherichia coli cell division components.

Diverse paths to midcell: assembly of the bacterial cell division machinery (Review).  N. W. Goehring and J. Beckwith.  Current Biology 15(13):R514-26 (2005).  PDF


IcsA, a polarly localized autotransporter with an atypical signal peptide, uses the Sec apparatus for secretion, although the Sec apparatus is circumferentially distributed.  L.D. Brandon, N. Goehring, A. Janakiraman, A. W. Yan, T. Wu, J. Beckwith and M. B. Goldberg.  Molecular Microbiology 50(1):45-60 (2003).  PDF

Proteophosphoglycans of Leishmania mexicana. Identification, purification, structural and ultrastructural characterization of the secreted promastigote proteophosphoglycan pPPG2, a stage-specific glycoisoform of amastigote aPPG.  C. Klein, U. Göpfert, N. Goehring, Y. D. Stierhof and T. Ilg.  Biochemical Journal 344:775-86(1999).  

Proteophosphoglycans of Leishmania mexicana. Molecular cloning and characterization of the Leishmania mexicana ppg2 gene encoding the proteophosphoglycans aPPG and pPPG2 that are secreted by amastigotes and promastigotes.  U. Göpfert, N. Goehring, C. Klein and T. Ilg.  Biochemical Journal 344:787-95 (1999).  PDF

Percussive Foraging: Stimuli for Prey Location by Aye-Ayes (Daubentonia madagascariensis).  C. J. Erickson, S. Nowicki, L. Dollar and N. Goehring.  International Journal of Primatology. (1998).


© Goehring Lab 2014